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用幽门螺杆菌 ( Hp)抗原加佐剂或用减毒沙门菌传递抗原的新免疫接种策略能成功地保护小鼠免受 Hp感染。口服 1剂表达脲酶的减毒沙门菌菌苗能诱导粘膜和全身抗体应答 ,并能完全保护不同品系小鼠免受 Hp感染。这种高效、高免疫原性、安全且低成本的菌苗是预防人类 Hp相关疾病有希望的候选菌苗
The new vaccination strategy with H. pylori (Hp) antigen plus adjuvant or with attenuated Salmonella delivery successfully succeeded in protecting mice from H. pylori infection. Oral administration of an attenuated Salmonella typhimurium vaccine expressing urease induced mucosal and systemic antibody responses and completely protected different strains of mice from H. pylori infection. This efficient, highly immunogenic, safe and low-cost vaccine is a promising candidate vaccine against Hp-related diseases in humans