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本文报道早期缺氧对器官培养的小鼠胎心超微结构和膜系统通透性的影响。用镧作为标记物进行超微结构研究证明,缺氧20分钟,可观察到镧颗粒穿过细胞膜进入细胞内,并呈节结状沉积在线粒体的周围,或有选择性地进入肿胀的线粒体内。在相同缺氧时间,酸性磷酸酶反应物沉积在细胞浆内,一些溶酶体和线粒体也有这种酶反应物围绕·电镜检查,缺氧40分钟,有细胞膜的部分缺失,线粒体内有大小不等的空泡,有时可见无定形的致密体。这些结果表明,线粒体、溶酶体和细胞膜可能是早期缺氧损伤的靶细胞器。
This article reports the effects of early hypoxia on fetal fetal heart ultrastructure and membrane system permeability in organ culture. Lanthanum as a marker for ultrastructure studies have shown that 20 minutes after hypoxia, the lanthanum particles can be observed through the cell membrane into the cells, and was nodular deposition in the mitochondria around the knot, or selectively into the swollen mitochondria . In the same hypoxia time, acidic phosphatase reactants deposited in the cytoplasm, some lysosomes and mitochondria also have this enzyme reactants around · electron microscopy, hypoxia 40 minutes, there is a partial lack of cell membrane, mitochondria within the size of And other vacuoles, and sometimes visible amorphous dense body. These results indicate that mitochondria, lysosomes and cell membranes may be target organelles for early hypoxia injury.