论文部分内容阅读
以逆转录病毒载体表达的反义ＲＮＡ技术已活跃于肿瘤研究及基因治疗领域，它为了解肿瘤的发生机制并从基因水平上根治肿瘤提出了一种可能的途径。反义ＲＮＡ是利用碱基互补原理，通过载体的介导特异性封闭或阻断有害基因的表达，从而达到治疗肿瘤的目的。它的发现和应用展示了人们的科学思维过程和哲学思想。但逆转录病毒作为载体的基因治疗具有两重性，只有充分认识并不断地改进，才能使基因治疗更趋完善。
Antisense RNA technology expressed in retroviral vectors has been active in the field of tumor research and gene therapy. It provides a possible way to understand the mechanism of tumorigenesis and eradicate tumors from the genetic level. Antisense RNA uses the principle of base-complementation to specifically block or block the expression of harmful genes through the mediation of vectors, thereby achieving the purpose of treating tumors. Its discovery and application demonstrate people’s scientific thinking process and philosophy. However, gene therapy with retrovirus as a vector has twofolds. Only full understanding and continuous improvement can make gene therapy more perfect.