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目的横断面调查重度急性胰腺炎(SAP)患者巨细胞病毒潜伏-激活感染血清学及临床特征,初步探讨SAP患者急性期巨细胞病毒激活情况。方法收集2013年10月-2015年9月医院急性胰腺炎(AP)住院476名患者血清标本,采用电化学发光法检测入院时HCMV-IgM和HCMV-IgG值,入院后14dSAP患者重复测定HCMV-IgM值,数据采用SPSS 17.0软件进行统计分析。结果入院时476例AP患者HCMV-IgG阳性率96.05%,重度96.67%,轻中度AP95.90%,两者比较差异无统计学意义;HCMV-IgM阳性率为9.87%,重度及轻中度AP患者HCMV-IgM阳性表达率分别为16.7%和6.6%,两者比较差异有统计学意义(P<0.05),入院后14d128例SAP患者HCMV-IgM阳性率为28.1%,与入院时比较差异无统计学意义。结论 SAP患者巨细胞病毒活动性感染率较轻中度AP高,且急性期存在巨细胞病毒潜伏再激活,与临床结局有关。
Objective To investigate the serological and clinical features of cytomegalovirus latent-activated infection in patients with severe acute pancreatitis (SAP) and to investigate the activation of cytomegalovirus in acute stage of SAP. Methods Serum samples of 476 hospitalized patients with acute pancreatitis (AP) from October 2013 to September 2015 were collected. The HCMV-IgM and HCMV-IgG levels were detected by electrochemiluminescence. The levels of HCMV- IgM values, the data using SPSS 17.0 software for statistical analysis. Results The positive rate of HCMV-IgG in 476 AP patients at admission was 96.05%, 96.67% with mild and moderate AP95.90%, the difference was not statistically significant; the positive rate of HCMV-IgM was 9.87%, severe and mild The positive rates of HCMV-IgM in AP patients were 16.7% and 6.6%, respectively, with significant difference (P <0.05). The positive rate of HCMV-IgM in 288 SAP patients after admission was 28.1% No statistical significance. Conclusions The active infection rate of cytomegalovirus in patients with SAP is higher than that of moderate to moderate AP, and latent reactivation of cytomegalovirus exists in acute phase, which is related to clinical outcome.