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目的 研究胃癌组织增殖细胞核抗原 (PCNA)表达意义。方法 应用免疫组织化学方法检测PCNA在 98例胃癌标本中的表达。结果 在 98例胃癌标本中 ,PCNA标记指数 (PCNALI)在 15 85 %～ 82 12 %之间 ,平均为5 2 17%± 11 4 6%。PCNALI在低分化胃癌 (直径 >5cm ,有淋巴结和其他脏器转移 )中的表达远高于高分化胃癌 (直径 <5cm ,无淋巴转移 )。以 5 0 %为界限 ,PCNALI>5 0 %者生存期短 ,5年生存率低。结论 PCNA对胃癌的诊断、分期、预后及治疗有重要价值
Objective To study the expression of proliferating cell nuclear antigen (PCNA) in gastric cancer. Methods The expression of PCNA in 98 gastric cancer specimens was detected by immunohistochemistry. Results In 98 gastric cancer samples, PCNA labeling index (PCNALI) was 15 85% -82 12% with an average of 52.17% ± 11 46%. The expression of PCNALI in poorly differentiated gastric cancer (diameter> 5cm, with lymph node and other organs metastasis) is much higher than that in well differentiated gastric cancer (diameter <5cm, without lymphatic metastasis). With a 50% limit, PCNALI> 50% have short survival and low 5-year survival. Conclusion PCNA has important value in the diagnosis, staging, prognosis and treatment of gastric cancer