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目的对比硫酸镁和硫酸镁与硝苯地平联用两种方法治疗妊高症的临床效果,探讨妊高症的更有效治疗方法。方法随机选取2015年1月至2016年12月于我院诊治的妊高症患者30例,将其分为A组和B组,每组各15例。A组仅采用硫酸镁治疗,B组在A组的基础上联用硝苯地平治疗。对比两组患者临床效果的差异、血压改善情况以及不良反应发生率的差异。结果 B组临床有效率为93.3%,显著高于A组的有效率73.3%;B组血压与24h尿蛋白定量改善情况优于A组;且B组(6.7%)不良反应发生率略低于A组(20.0%),以上差异均有统计学意义(P<0.05)。结论硫酸镁联合硝苯地平治疗妊高症可以有效稳定患者血压至正常水平、临床有效率较高且较少引起不良反应的发生,在保证母婴安全上有重要价值。
Objective To compare the clinical effects of magnesium sulfate, magnesium sulfate and nifedipine in treating pregnancy-induced hypertension (PIH) and to explore more effective treatment for PIH. Methods Thirty patients with pregnancy induced hypertension who were diagnosed and treated in our hospital from January 2015 to December 2016 were selected randomly and divided into groups A and B, 15 cases in each group. Group A was treated with magnesium sulfate only, while group B was treated with nifedipine on the basis of group A. The difference of clinical effect, the improvement of blood pressure and the incidence of adverse reactions between the two groups were compared. Results The clinical effective rate in group B was 93.3%, which was significantly higher than that in group A (73.3%). The improvement of blood pressure and 24h urinary protein in group B was better than that in group A, and the incidence of adverse reactions in group B (6.7%) was slightly lower than that in group B Group A (20.0%), the above differences were statistically significant (P <0.05). Conclusion Combination of magnesium sulfate and nifedipine in the treatment of pregnancy-induced hypertension can effectively stabilize the patients’ blood pressure to a normal level. The higher clinical efficiency and fewer adverse reactions are of great value in ensuring the safety of mother and infant.