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以氯霉素为原料,经水解、叔胺化、季铵化合成了光学纯(1S,2R)-(-)-(1-对硝基苯基-1,3-二羟基-2-丙基)三甲基 碘化铵,作为相转移催化剂,它对苯乙腈的α-甲基化、苯甲醛与氯仿的亲核加成均显示良好的催化作用和一定的不对称 诱导效应。
(1S, 2R) - (-) - (1-p-nitrophenyl-1,3-dihydroxy-2-propan-1-ol ) As trimethylammonium iodide, as a phase transfer catalyst, its α-methylation of benzene acetonitrile, nucleophilic addition of benzaldehyde and chloroform both showed good catalysis and a certain degree of asymmetric induction.