随着对睡眠呼吸暂停综合征(SAS)的认识及研究的不断加深,人们开始关注其在分子水平的发病根源,包括5-羟色胺、腺苷与瘦素(leptin)。1988年,美国德克萨斯大学达拉斯的西南中心的实验小组在寻找与孤儿G蛋白偶联的细胞表面受体(GPCRs)相连的配基时,在大鼠脑组织提取物中,发现2种神 With the understanding of sleep apnea syndrome (SAS) and the deepening of research, people began to pay attention to its pathogenesis at the molecular level, including serotonin, adenosine and leptin. In 1988, an experimental group at the southwestern center of Dallas, University of Texas, in finding brain ligands that were linked to orphan G protein-coupled cell surface receptors (GPCRs), found two God