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目的 研究谷氨酸转运蛋白亚型 (EAAC- 1)在红藻氨酸 (KA)诱导癫痫发作大鼠海马结构中的变化 .方法 用红藻氨酸诱导的复杂部分性癫痫模型 ,将 2 0只 SD大鼠随机分为3,6 ,12 ,48h及对照 5组 .用免疫蛋白印记法 (Western blot)观察 EAAC- 1在海马结构上的变化 .结果 KA注射后 3h海马 EAAC- 1开始减少 ,6 h显著减少 ,12 h后 EAAC- 1逐渐恢复 .结论 EAAC- 1表达的调控可能与 KA诱导的癫痫发作、神经毒性作用以及在神经元的可塑性中起十分重要的作用
Objective To study the changes of the glutamate transporter subtype (EAAC-1) in hippocampal formation induced by kainate (KA) -induced epilepsy in rats.Methods The model of complex partial epilepsy induced by kainic acid Only SD rats were randomly divided into 3 groups, 6, 12 and 48 hours, and control group 5. The changes of EAAC-1 in hippocampus were observed by Western blot.Results EAA-1 began to decrease in hippocampus 3 hours after KA injection , Decreased significantly at 6 h and gradually recovered at 12 h.Conclusion The regulation of EAAC-1 expression may play an important role in KA-induced seizures, neurotoxicity and neuronal plasticity