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目的 :研究部分脾栓塞治疗脾功能亢进对肝硬化患者T淋巴细胞亚群的影响。方法 :57例肝硬化并脾功能亢进患者 ,32例采用部分脾栓塞治疗 ,2 5例采用脾全切治疗 ,1 5例正常人作为对照 ,比较两组治疗前后外周血T淋巴细胞亚群的变化。结果 :肝硬化患者外周血T淋巴细胞 (CD3+ )、T辅助 /诱导淋巴细胞亚群 (CD4+ )、T辅助淋巴细胞 /T抑制淋巴细胞亚群 (CD4+ /CD8+ )明显低于正常人 (P <0 .0 1 ) ;脾栓塞组治疗前后CD3+ 、CD4+ 、CD8+ 、CD4+ /CD8+ 无明显差异 (P >0 .0 5) ;脾全切组治疗后CD3+ 、CD4+ 、CD4+ /CD8+ 均较治疗前及部分脾栓塞组治疗后明显降低 (P <0 .0 1 )。结论 :肝硬化患者外周血CD3+ 、CD4+ 、CD4+ /CD8+ 降低 ,部分脾栓塞治疗脾功能亢进 ,对肝硬化患者外周血T淋巴细胞亚群无明显影响 ,显著优于脾全切治疗
Objective: To study the effect of partial splenic embolization on T lymphocyte subsets in cirrhotic patients with hypersplenism. Methods: Fifty-seven patients with cirrhosis and hypersplenism, 32 patients received partial splenic embolization, 25 patients received splenectomy and 15 normal subjects served as controls. The levels of T lymphocyte subsets in peripheral blood before and after treatment were compared Variety. Results: The levels of T lymphocyte (CD3 +), T helper / induced lymphocyte subsets (CD4 +) and T helper lymphocyte / T lymphocyte subsets (CD4 + / CD8 +) in patients with cirrhosis were significantly lower than those in normal controls (P < There was no significant difference in the levels of CD3 +, CD4 +, CD8 + and CD4 + / CD8 between the splenic embolization group before and after treatment (P> 0.05). The levels of CD3 +, CD4 +, CD4 + / CD8 + Some splenic embolization group was significantly lower after treatment (P <0.01). Conclusion: The decrease of CD3 +, CD4 +, CD4 + / CD8 + in peripheral blood of patients with cirrhosis and partial splenic embolization in the treatment of hypersplenism has no obvious effect on T lymphocyte subsets in peripheral blood of cirrhotic patients, which is significantly better than that of splenectomy