存在于人免疫细胞表面的IgG Fcγ受体(FcγRs)在功能上分为活化性受体和抑制性受体两类,其主要的免疫学作用是对细胞反应的正向和负向调节,两者间相互作用的平衡是维持机体正常免疫应答或免疫耐受的重要因素,由此FcγRs也成为潜在的治疗自身免疫病、过敏及感染性疾病等理想的作用靶标。现就人FcγRs在不同免疫效应细胞表面的分布及其免疫调节功能的研究进展作一概述。 The IgG Fcγ receptors (FcγRs) present on the surface of human immune cells are functionally divided into two classes, an active receptor and an inhibitory receptor, whose primary immunological effects are the positive and negative regulation of cellular responses. Two The balance between the interaction is an important factor to maintain the normal immune response or immune tolerance of the body, thus FcγRs has also become a potential target for the treatment of autoimmune diseases, allergies and infectious diseases. Now on the human FcγRs in different immune effector cells on the surface of the distribution and immune regulatory functions are reviewed.