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目的 研究肿瘤坏死因子相关凋亡诱导配体 (TRAIL)和肿瘤坏死因子相关凋亡诱导配体受体(TRAILR)在甲状腺癌中的表达及意义。 方法 采用免疫组织化学方法 ,检测 5例正常甲状腺、13例乳头状甲状腺癌、3例滤泡状甲状腺癌和 12例甲状腺癌旁组织中TRAIL和TRAILR的表达和分布。 结果 乳头状、滤泡状甲状腺癌组织和正常甲状腺组织中的甲状腺滤泡细胞均表达TRAIL和全部的TRAILR ,其中诱捕受体TRAILR4在正常甲状腺组织和甲状腺癌旁组织表达较弱。 结论 甲状腺癌组织中的甲状腺滤泡细胞表达TRAIL和全部的TRAILR ,提示癌变的甲状腺滤泡细胞通过自身表达TRAIL ,以自分泌或旁分泌的形式和其死亡受体TRAILR1、TRAILR2结合 ,诱导癌变的甲状腺滤泡细胞发生凋亡 ,诱捕受体TRAILR3、TRAILR4的存在也不能影响其对TRAIL诱导的细胞凋亡的敏感性
Objective To study the expression and significance of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and tumor necrosis factor-related apoptosis-inducing ligand receptor (TRAILR) in thyroid cancer. Methods Immunohistochemistry was used to detect the expression and distribution of TRAIL and TRAILR in 5 cases of normal thyroid, 13 cases of papillary thyroid carcinoma, 3 cases of follicular thyroid carcinoma and 12 cases of parathyroid carcinoma. Results TRAIL and TRAILR were all expressed in thyroid follicular cells in papillary, follicular thyroid carcinoma and normal thyroid tissues. TRAILR4, a trapping receptor, expressed weakly in normal thyroid tissues and adjacent thyroid tissues. Conclusions Thyroid follicular cells in thyroid cancer express TRAIL and all TRAILR, which suggests that thyroid follicular cells can induce carcinogenesis by their own expression of TRAIL in an autocrine or paracrine manner with their death receptors TRAILR1 and TRAILR2 Thyroid follicular cells undergo apoptosis, and the presence of trapping receptors TRAILR3 and TRAILR4 can not affect their sensitivity to TRAIL-induced apoptosis