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对膀胱粘膜良、恶性病变进行了核ＤＮＡ含量研究，其中不典型增生（Ⅱ、Ⅲ级），乳头状瘤各５例，移行细胞癌４５例（Ｉ、Ⅱ、Ⅲ级各１５例），正常膀胱粘膜５例。结果显示：正常粘膜，不典型增生主要为２Ｃ细胞，乳头状瘤以３Ｃ为主，且部分不典型增生和乳头状瘤核ＤＮＡ含量与移行细胞癌Ⅰ级相近。提示不典型增生和乳头状瘤中部分病例有恶变可能。移行细胞癌随分级升高而ＤＮＡ含量递增，非倍体、Ｓ期细胞增多，各级间以及与不典型增生和乳头状瘤间相差非常显著（ｐ＜０．０ｌ）。随访结果显示随着分级升高ＤＮＡ含量增加而复发率、死亡率上升，故ＤＮＡ含量检测有助于临床判断预后。
The nuclear DNA content of benign and malignant bladder mucosa were studied, including atypical hyperplasia (grade Ⅱ, Ⅲ), 5 cases of papilloma, 45 cases of transitional cell carcinoma (15 cases of grade I, Ⅱ and Ⅲ), normal Bladder mucosa in 5 cases. The results showed that: normal mucosa, atypical hyperplasia mainly 2C cells, papilloma mainly 3C, and some atypical hyperplasia and papilloma nuclear DNA content and grade Ⅰ similar to transitional cell carcinoma. Tip dysplasia and papilloma in some cases may malignant. With the increase of grade, the content of DNA in esophageal cancer was increased, the number of nonploidy and S phase cells increased, and the difference between esophageal squamous cell carcinoma and atypical hyperplasia and papilloma was significant (p <0.01). The follow-up results showed that the recurrence rate and the death rate increased with the increase of DNA content in grading, so the detection of DNA content would be helpful to the clinical judgment of prognosis.