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目的探讨胶质瘤相关癌基因蛋白1(GLI-1)和MMP-9在乳腺癌中的表达及临床意义。方法采用免疫组化检测69例乳腺癌组织、30例癌旁组织中GLI-1和MMP-9的表达,并分析GLI-1、MMP-9表达与乳腺癌临床病理特征的关系。结果 GLI-1和MMP-9在乳腺癌组织的阳性表达率高于癌旁组织(65.2%vs.13.3%和68.1%vs.16.7%)(P<0.05)。GLI-1和MMP-9的阳性表达与患者年龄、肿瘤大小、病理分级以及孕激素受体、人表皮生长因子受体2的阳性表达无明显相关性(P>0.05),而与淋巴结转移、TNM分期密切相关(P<0.05),同时GLI-1也与雌激素受体阳性表达相关(P<0.05)。乳腺癌组织GLI-1与MMP-9的表达呈正相关(r=0.273,P<0.05)。结论GLI-1和MMP-9在乳腺癌组织中阳性表达率高;联合检测GLI-1和MMP-9有助于判断乳腺癌的恶性程度和生物学行为。
Objective To investigate the expression and clinical significance of glioma-associated oncogene 1 (GLI-1) and MMP-9 in breast cancer. Methods The expression of GLI-1 and MMP-9 in 69 cases of breast cancer tissues and 30 cases of paracancer tissues were detected by immunohistochemistry. The relationship between the expression of GLI-1, MMP-9 and clinicopathological features of breast cancer was analyzed. Results The positive rates of GLI-1 and MMP-9 in breast cancer tissues were significantly higher than those in paracancer tissues (65.2% vs.13.3% and 68.1% vs.16.7%, respectively) (P <0.05). The positive expression of GLI-1 and MMP-9 had no significant correlation with the age, tumor size, pathological grade and the positive expression of progesterone receptor and human epidermal growth factor receptor 2 (P> 0.05), but not with lymph node metastasis, TNM stage (P <0.05), and GLI-1 was also correlated with estrogen receptor positive expression (P <0.05). The expression of GLI-1 and MMP-9 in breast cancer tissues was positively correlated (r = 0.273, P <0.05). Conclusion The positive rates of GLI-1 and MMP-9 in breast cancer tissues are high. Combined detection of GLI-1 and MMP-9 may be helpful in judging the malignant degree and biological behavior of breast cancer.