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目的研究乙型肝炎患者血清细胞因子水平与肝纤维化的关系。方法检测 ８０例乙型肝炎患者及 ２０例正常对照的血清肿瘤坏死因子（ＴＮＦ－α）和血小板源生长因子（ＰＤＧＦ）水平。结果急性肝炎、慢性肝炎和肝硬化患者的ＴＮＦ和ＰＤＧＦ的活性明显高于正常对照组，且与患者的血清Ⅲ型前胶原肽（ＰＣⅢ）含量密切相关（ ｒ＝ ０．６６， ｒ＝ ０．７５）。结论 ＴＮＦ－α和 ＰＤＧＦ活性的变化可能与肝纤维化的发病机理有关，在慢性肝炎向肝硬化转变的过程中起促进作用。
Objective To study the relationship between serum levels of cytokines and hepatic fibrosis in patients with hepatitis B Methods Serum levels of tumor necrosis factor (TNF-α) and platelet-derived growth factor (PDGF) were measured in 80 patients with hepatitis B and 20 healthy controls. Results The activity of TNF and PDGF in patients with acute hepatitis, chronic hepatitis and cirrhosis was significantly higher than that in the normal control group, and was closely related to the level of PC Ⅲ in patients with acute hepatitis, chronic hepatitis and cirrhosis (r = 0.66, r = 0). 75). Conclusion The changes of the activity of TNF-α and PDGF may be related to the pathogenesis of hepatic fibrosis and play a role in the process of the transformation from chronic hepatitis to cirrhosis.