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本文98例停经≤49天要求终止妊娠的妇女,随机分为三组:Ⅰ、Ⅱ组均口服米非司酮25mg,2次/日,连服5次;Ⅲ组一次口服200mg第三天上午,Ⅰ组阴道放置PG05栓1mg;Ⅱ、Ⅲ组均口服米索前列醇600μg.完全流产率96.9%,不全流产率2.0%,1例继续妊娠(1.0%),三组间无显著性差异(P>0.05)。除Ⅰ组有7例腹泻(24.1%.1%),与Ⅱ、Ⅲ组间有显著性差异(P<0.01)Ⅲ组中1例呕吐严重补液治疗外,药物所致副反应轻微,不需处理。结果提示三种用药方案用于抗早孕,安全、有效率高。本文对三组对象于妊娠终止前后作血清β-hCG、E2.P,PRL及皮质醇测定并进行对比。
This article 98 cases of menopausal women ≤ 49 days of termination of pregnancy were randomly divided into three groups: Ⅰ, Ⅱ were oral mifepristone 25mg, 2 times / day, and even served 5 times; Ⅲ group once orally with 200mg the third morning , PG05 suppository was placed in the vagina of group Ⅰ, and 600 μg of misoprostol was administered to the patients in group Ⅱ and Ⅲ. Complete abortion rate of 96.9%, incomplete abortion rate of 2.0%, 1 case of continued pregnancy (1.0%), no significant difference between the three groups (P> 0.05). In addition to 7 cases of diarrhea (24.1% .1%) in group Ⅰ, there was a significant difference between group Ⅱ and Ⅲ (P <0.01). One case of vomiting severe rehydration therapy in group Ⅲ, drug side effects Slight, do not need to deal with. The results suggest that three kinds of drug regimens for anti-pregnancy, safety, high efficiency. This article on the three groups before and after termination of pregnancy for serum β-hCG, E2. P, PRL and cortisol were measured and compared.