论文部分内容阅读
目的探讨绝经后子宫内膜癌患者三维能量多普勒超声血流定量参数及与血清基质金属蛋白酶-2(MMP-2)及尿激酶型纤溶酶原激活物(u PA)的相关性。方法分析2014年1月-2016年3月在昆山市第三人民医院接受治疗的41例子宫内膜癌患者的临床资料并列为观察组,选取38例子宫良性病变患者作为对照组。观察两组女性和其中的淋巴结转移组与未转移组的三维能量超声FI、RI、VI及PSV参数,淋巴结转移组与未转移组IL-6、MMP-2、u PA水平的比较及淋巴结转移组中血清MMP-2、u PA与VI指数的相关性分析。结果观察组患者RI、VI及PSV血流参数明显低于对照组,FI指数明显高于对照组,差异有统计学意义(P<0.05);淋巴结转移组VI指数、MMP-2及u PA水平明显高于未转移组,差异有统计学意义(P<0.05);淋巴结转移组患者血清MMP-2、u PA与VI指数均呈正相关(P<0.05)。结论三维能量多普勒超声对子宫内膜癌伴淋巴结转移患者具有一定诊断的价值,血清MMP-2、u PA与VI指数均呈正相关,侧面反映病灶内血管新生的机制。
Objective To investigate the relationship between the quantitative parameters of three-dimensional energy Doppler flow and the levels of serum matrix metalloproteinase-2 (MMP-2) and urokinase-type plasminogen activator (uPA) in postmenopausal women with endometrial cancer. Methods The clinical data of 41 patients with endometrial cancer treated in the Third People’s Hospital of Kunshan from January 2014 to March 2016 were selected as the observation group and 38 patients with benign uterine lesions were selected as the control group. The levels of IL-6, MMP-2, u PA in lymph node metastasis and non-metastatic lymph nodes were compared between the two groups of women and the lymph node metastasis and non-metastasis groups Correlation analysis of serum MMP-2, u PA and VI index in the group. Results The flow parameters of RI, VI and PSV in the observation group were significantly lower than those in the control group, and the FI index was significantly higher than that in the control group (P <0.05). The levels of VI, MMP-2 and u PA in lymph node metastasis (P <0.05). There was a positive correlation between serum MMP-2, u PA and VI index in patients with lymph node metastasis (P <0.05). Conclusions Three-dimensional energy Doppler ultrasound is of value in the diagnosis of endometrial carcinoma with lymph node metastasis. Serum MMP-2, u PA and VI index are positively correlated, and the mechanism of angiogenesis in lesion is reflected laterally.