论文部分内容阅读
目的观察人体胚胎骨髓造血组织细胞的发生、发展规律，微环境的变化，以及对白血病诊断的意义。方法对９３例１～１０个月胚胎骨髓组织进行塑料包埋、半薄切片、Ｈ－Ｇ－Ｅ及组化染色观察。结果胚１月卵黄囊与羊膜囊周出现有核红细胞造血岛。胚２月软骨母细胞首先进入髓腔，骨髓微环境形成。胎３月骨髓出现各系各阶段造血细胞，胎儿期骨髓红粒比值始终倒置，以幼稚期血细胞为主，红粒系幼稚细胞成簇状聚集排列。胎５月骨髓出现脂肪，骨髓间质网纤与纤维细胞量少，中性粘蛋白为主。结论胚胎骨髓造血最早始于胚外中胚层的间充质细胞。胎３个月开始骨髓造血。软骨母细胞可能是髓内造血组织各种细胞的共同祖先，造血祖细胞是多源性的。胚胎期骨髓象类似髓性白血病。胎５月出现黄髓。组织结构变化比细胞形态变化对白血病的诊断更有指导意义。ＭＤＳ的诊断以髓索中央出现ＡＬＩＰ更确诊。
Objective To observe the occurrence and development of human embryonic bone marrow hematopoietic cells, the changes of microenvironment, and the significance of leukemia diagnosis. Methods Ninety-three cases of embryonic bone marrow from 1 to 10 months were embedded in plastic, semi-thin section, H-G-E and histological staining. Results There were nucleated hematopoietic cells of erythrocytes in yolk sac and amniotic sac in January. Embryo February chondroblasts first enter the medullary cavity, bone marrow microenvironment formation. In March, the bone marrow of each fetus appeared hematopoietic cells in all stages of the fetus. The ratio of red blood cells in the bone marrow of the fetus was inverted all the time, mainly in the naive blood cells, and the erythroid granulocytes were clustered in clusters. Fetal bone marrow appeared fat in May, bone marrow stromal network fiber and fiber cells less, mainly neutral mucin. Conclusion The embryonic bone marrow hematopoietic cells originated from the mesodermal mesenchymal cells. 3 months fetal birth bone marrow. Chondroblasts may be the common ancestor of various cells in hematopoietic tissue of the marrow, and hematopoietic progenitor cells are multi-sourced. Embryonic bone marrow like myeloid leukemia. May birth of yellow marrow in May. Changes in organizational structure than the changes in cell morphology leukemia diagnosis more instructive. The diagnosis of MDS with medullary ALIP more confirmed.