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目的:探讨茵栀黄颗粒联合蓝光治疗新生儿高胆红素血症的护理要点。方法:以该院儿科2011年6月—2013年6月收治的62例高胆红素血症患儿为研究对象,采用随机数字法分为对照组(n=30)和观察组(n=32);两组患者均给予茵栀黄颗粒联合蓝光治疗,观察组在此基础上给予光疗和服药护理;对比两组患儿的临床疗效、不良反应及治疗过程中胆红素变化情况,并比较其治疗前后肝功能指标ALT、AST、GGT、ALP、ALB及GLB的血清水平。结果:观察组总有效率明显高于对照组(96.88%VS 76.67%,P<0.05),不良反应发生率显著低于对照组(3.13%VS 36.67%,χ2=11.2,P<0.01)。治疗前,两组患者的血清胆红素水平无组间差异(P>0.05),治疗后3 d、7 d,观察组T-BILI和I-BILI水平均显著低于对照组(P<0.05);治疗前,两组患儿的肝功能指标亦无组间差异,治疗后,观察组ALT、AST、GGT、ALP水平显著低于对照组(P<0.05)。结论:在茵栀黄颗粒联合蓝光治疗新生儿高胆红素血症过程中需要加强护理以防止红臀、皮疹等不良反应的发生。
Objective: To explore the main points of nursing of Yinzhihuang granule combined with blue light in the treatment of neonatal hyperbilirubinemia. Methods: Sixty-two children with hyperbilirubinaemia admitted to our hospital from June 2011 to June 2013 were divided into control group (n = 30) and observation group (n = 32). Both groups were treated with Yinzhihuang granule combined with blue light. The observation group was given phototherapy and medication care on this basis. The clinical curative effect, adverse reactions and bilirubin in the treatment were compared The serum levels of ALT, AST, GGT, ALP, ALB and GLB before and after treatment were compared. Results: The total effective rate in the observation group was significantly higher than that in the control group (96.88% vs 76.67%, P <0.05). The incidence of adverse reactions was significantly lower in the observation group than in the control group (3.13% vs 36.67%, χ2 = 11.2, P <0.01). Before treatment, the levels of serum bilirubin in two groups had no significant difference (P> 0.05). The levels of T-BILI and I-BILI in observation group were significantly lower than those in control group on the 3rd and 7th day after treatment (P <0.05 Before treatment, there was no difference between the two groups in liver function index. After treatment, the levels of ALT, AST, GGT and ALP in the observation group were significantly lower than those in the control group (P <0.05). Conclusion: Yinzhihuang particles combined with blue light treatment of neonatal hyperbilirubinemia need intensive care to prevent red buttocks, skin rashes and other adverse reactions.