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目的探讨特发性甲状旁腺功能减退症神经精神表现的临床特征。方法对48例特发性甲状旁腺功能减退症患者进行回顾性总结,分析其所并发的神经精神表现及对治疗的反应。结果特发性甲状旁腺功能减退症最常见的神经精神症状依次为记忆力减退(47.9%)、癫痫发作(33.3%)、情感障碍(25%)和智能障碍(25%);较少见的有锥体外系症状(10.4%)、行为异常(4.2%)、四肢无力(4.2%)、痴呆(2.1%)和谵妄(2.1%)等。经补充钙剂、维生素D以及对症治疗,症状大部分可缓解。结论特发性甲状旁腺功能减退症的神经精神症状广泛,发生率较高,其发生与低血钙有关,疗效较好。
Objective To investigate the clinical features of neuropsychiatric manifestations of idiopathic hypoparathyroidism. Methods 48 patients with idiopathic hypoparathyroidism were retrospectively reviewed, and their neuropsychiatric performance and response to treatment were analyzed. Results The most common neuropsychiatric symptoms of idiopathic hypoparathyroidism were memory loss (47.9%), seizures (33.3%), affective disorders (25%) and mental retardation (25%). Less common There were extrapyramidal symptoms (10.4%), abnormal behavior (4.2%), weakness in limbs (4.2%), dementia (2.1%) and delirium (2.1%). After the addition of calcium, vitamin D and symptomatic treatment, most of the symptoms can be alleviated. Conclusions Idiopathic hypoparathyroidism has a wide range of neuropsychiatric symptoms with a high incidence, which is associated with hypocalcemia and has good efficacy.