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本文应用免疫组织化学方法研究了95例喉癌组织中组织相容性Ⅱ类抗原—HLA-DR表达情况,95例患者的喉癌组织中有29例(30.5%)HLA-DR阳性,66例(69.5%)阴性.而6例喉正常粘膜上皮及61例癌旁上皮均为阴性.统计分析发现HLA-DR阳性的标本分化程度高者(82.8%)明显多于HLA-DR阴性者(56.1%)(P<0.05),前者的5年生存率为79.6%,高于后者的5年生存率70.5%(0.1>P>0.05).HLA-DR阳性与否与患者的年龄,性别、肿瘤的T、N分期、局部和区域复发、远地转移无关(P>0.05).说明HLA-DR异常表达的癌组织分化程度高.
In this study, the immunohistochemical method was used to investigate the expression of HLA-DR in 95 cases of laryngeal carcinoma. HLA-DR was positive in 29 cases (30.5%) of the laryngeal carcinoma in 95 cases and in 66 cases (69.5%) were negative, while 6 cases of laryngeal normal mucosa epithelium and 61 cases of paracancerous epithelium were negative.Statistical analysis showed that HLA-DR positive specimens were more differentiated (82.8%) than HLA-DR negative ones %) (P <0.05). The 5-year survival rate of the former was 79.6%, which was higher than the latter’s 5-year survival rate of 70.5% (P0.05) .The positive or negative correlation between HLA-DR and age, sex, T, N staging, local and regional recurrence, distant metastasis (P> 0.05), indicating that HLA-DR abnormal expression of cancer tissue differentiation is high.