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作者采用脉冲性口服大剂量强的松龙治疗了17例未经筛选的最低限度接受过常规治疗3个月无效或复发的多发性骨髓瘤。病人和方法患者平均年龄61岁。剂量为60mg/M~2,连用5天,间歇9天,以后按此剂量和间歇时间周期性进行治疗。用药期间加用雷尼替丁和制霉素,以减少胃溃疡和口腔念珠茵病。临床有放疗指征者给予局部放射治疗,并嘱患者多饮水。治疗至少12周(即6个周期)后进行疗效评定。良好疗效是血清异常蛋白减少超过50%,尿无轻链排出,持续至少12周;部份疗效是血清异常蛋白降低25～49%,尿轻链减少50%,维持12周以上。稳定期超过3个月者改为每月1次疗法,病情稳定6个月后停药。结果良好疗效者5例,部份疗效者5例,4例无效,3例因治疗未足12周死亡,未作统计。中位数存活时间为22个月,良好疗效者中位数存活时间超过29个月,部份疗效者中位数存活时间19个月,无效者
The authors used a pulsatile oral dose of prednisolone to treat 17 patients with multiple myeloma who had not screened for minimal or no recurrence after 3 months of treatment. Patients and Methods Patients average age 61 years. The dose of 60mg / M ~ 2, once every 5 days, intermittent 9 days, after this dose and intermittent time periodically for treatment. During treatment with ranitidine and nystatin, to reduce gastric ulcer and oral prayer beads disease. Clinical indications of radiotherapy given local radiotherapy, and Zhu Huanzhe more water. The curative effect was evaluated after at least 12 weeks (ie 6 cycles) of treatment. Good curative effect is the reduction of abnormal protein in serum by more than 50%, excretion of urine without light chain for at least 12 weeks; partial curative effect is reduction of serum abnormal protein by 25-49% and urine light chain by 50% for more than 12 weeks. Stabilization period of more than 3 months to a monthly therapy, stable condition after 6 months withdrawal. The results of good effect in 5 cases, partial effect in 5 cases, 4 cases were ineffective, 3 cases were treated for less than 12 weeks of death, no statistics. The median survival time was 22 months. The median effective survival time was more than 29 months. The median survival time was 19 months in some patients.