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目的 探讨MIC1粘蛋白在乳腺肿瘤组织中的表达特征及其生物学和临床意义。方法 应用免疫组织化学ABC法对 15例乳腺非典型增生 ,15例乳腺良性肿瘤 ,44例乳腺癌 (2 1例含癌旁组织 )染色 ,观察MUC1在不同类型乳腺组织中的表达特征及其与雌激素受体和孕激素受体表达的关系。结果 MUC1在所检测的乳腺组织中均表达 ,但在不同病变乳腺组织中其表达的方式和强度不同。在癌旁和非典型增生组织中只表达在近管腔或腺腔侧的胞膜上 ,胞浆未见表达。在乳腺癌组织中整个胞膜和胞浆均表达 ,且表达强度与细胞的恶性化程度成正相关 (P <0 0 1)。浸润性癌中MUC1表达明显强于原位癌 (P <0 0 0 5 ) ;乳腺癌组织中MUC1的表达强度与雌激素受体的表达成正相关 (P <0 0 5 ) ,与孕激素受体表达无关 (P >0 0 5 )。乳腺癌组织中MUC1有旁分泌现象。结论 MUC1表达水平可反映乳腺肿瘤恶性化程度 ,并可能作为乳腺癌治疗效果判断和预后评价的参考指标。
Objective To investigate the expression of MIC1 mucin in breast neoplasms and its biological and clinical significance. Methods Fifteen cases of atypical breast hyperplasia, 15 cases of breast benign tumor and 44 cases of breast cancer (21 cases with paracancerous tissues) were stained with immunohistochemical ABC method to observe the expression of MUC1 in different types of breast tissues and their relationship with Relationship between estrogen receptor and progesterone receptor expression. Results MUC1 was detected in all tested breast tissues, but its expression was different in intensity and intensity in different pathological breast tissues. In the adjacent and atypical hyperplasia tissue only in the proximal lumen or the luminal side of the cell membrane, the cytoplasm was not expressed. The whole cell membrane and cytoplasm were expressed in breast cancer tissues, and the expression intensity was positively correlated with the degree of cell malignancy (P <0.01). The expression of MUC1 in invasive carcinoma was significantly higher than that in carcinoma in situ (P <0.05). The expression intensity of MUC1 in breast cancer was positively correlated with the expression of estrogen receptor (P <0.05) Body expression was not related (P> 0.05). MUC1 in breast cancer has paracrine phenomenon. Conclusion The expression of MUC1 may reflect the malignant degree of breast cancer, and may be used as a reference index for judging the prognosis and prognosis of breast cancer.