引言药理学治疗必须根据治疗目的及对相关正常生理学知识的理解.临床应用GnRH是在缺乏内源性GnRH脉冲时,通过使用外源性GnRH,脉冲频率为0.5～1次/小时,以模拟生理的脉冲形式达刺激性腺机能.相反,通过持续或半持续应用GnRH类似物(激动剂或纯拮抗剂),使垂体持续接触GnRH致垂体失敏感,可达抑制性腺的机能.因此,基于GnRH及其类似物的药代动力学及靶系统的药物动力学,应使用不同的适宜给药方式及治疗程序.本文综述GnRH及其类 Introduction Pharmacological treatment must be based on the purpose of treatment and the understanding of the relevant normal physiological knowledge. Clinical Applications GnRH, in the absence of endogenous GnRH pulses, uses exogenous GnRH at a pulse frequency of 0.5 to 1 time per hour to simulate physiological Of the pulse form of stimulating gonadal function.Conversely, continuous or semi-continuous application of GnRH analogs (agonists or pure antagonists), so that the pituitary ghrelin constant contact with the pituitary-sensitive, up to inhibit gonadal function.Therefore, based on GnRH and The pharmacokinetics of its analogues and the pharmacokinetics of the target system should be different from the appropriate mode of administration and treatment procedures.This paper reviews GnRH and its class