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目的探讨妊娠期肝内胆汁淤积症患者血清胆汁酸水平对围生儿结局的影响。方法选取2014年6月-2016年6月收治的90例妊娠期肝内胆汁淤积症患者作为观察组,另选择同期收治的90例健康孕妇作为对照组。比较两组孕妇血清及胎儿脐血胆汁酸水平及围生儿结局。结果观察组孕妇血清及胎儿脐血胆汁酸水平均高于对照组,差异均有统计学意义(P<0.05)。Spearman相关性分析显示:观察组胎儿脐血胆汁酸水平与孕妇血清胆汁酸水平呈正相关(r=0.982,P<0.05)。与对照组相比,观察组新生儿Apgar评分较低,新生儿窒息率、围生儿死亡率及早产率均较高,差异均有统计学意义(P<0.05)。结论检测孕妇血清及胎儿脐血胆汁酸水平具有重要意义,可为评估围生儿结局提供一定的理论基础。
Objective To investigate the effect of serum bile acid level on perinatal outcome in patients with intrahepatic cholestasis of pregnancy. Methods Ninety patients with intrahepatic cholestasis of pregnancy admitted from June 2014 to June 2016 were selected as the observation group and 90 healthy pregnant women were selected as the control group. The bile acid level and perinatal outcome in serum and fetal umbilical cord blood of two groups were compared. Results The bile acid levels of serum and fetus in the observation group were higher than those in the control group (P <0.05). Spearman correlation analysis showed that there was a positive correlation between bile acid level in fetal umbilical cord blood and serum bile acid level in pregnant women (r = 0.982, P <0.05). Compared with the control group, the neonatal Apgar score in observation group was lower, neonatal asphyxia, perinatal mortality and premature birth rate were higher, the difference was statistically significant (P <0.05). Conclusion Detection of serum and fetal umbilical blood bile acid levels of pregnant women is of great significance, which can provide some theoretical basis for the assessment of perinatal outcome.