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多数三唑类化合物具有强内吸性、广谱性、长效性和立体选择性等特性,近40年来被广泛地研究和应用。三唑类杀菌剂是指含有三氮唑的化合物。20世纪60年代中期,荷兰开发出第一个1,2,4-三唑类杀菌剂——威菌灵。20世纪70年代,三唑类化合物的高效杀菌活性引起国际农药界的高度重视,人们发现N-甲基碳上的取代基团可以广泛地被其它基团所取代,而其生物活性保持不变或有所提高。通过取代基团的变换,合成并筛选出一批具有杀菌活性的三唑类化合物。
Most triazole compounds have strong internal absorption, broad spectrum, long-acting and stereoselectivity, and have been widely studied and applied for nearly 40 years. Triazole fungicides refer to compounds containing triazole. In the mid 1960s, the Netherlands developed the first 1,2,4-triazole bactericide, Vigan. In the 1970s, the high bactericidal activity of triazole compounds attracted great attention from the international pesticide industry. It was found that substitution groups on N-methyl carbon could be widely replaced by other groups while their biological activities remained unchanged Or improved. A series of triazole compounds with bactericidal activity were synthesized and screened through the substitution of substitution groups.