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采用Ｉｏｄｏｇｅｎ法将放射性１３１Ｉ与花生凝集素（ＰＮＡ）进行标记，经腹腔注射１３１Ｉ－ＰＮＡ标记物到荷人胃癌裸鼠体内，在不同时间测定组织放射分布和γ照相。给药后第３天，肿瘤组织放射性强度是血液的４．３０倍，是正常肝组织的３．７６倍，是肌肉组织的３．８９倍；给药后第７天，肿瘤组织浓集１３１Ｉ－ＰＮＡ是正常胃组织的４．２１倍，是小肠组织的６．０５倍，是大肠组织的５．１３倍。４８小时可见肿瘤显像，７２小时显像清晰。本实验结果表明，凝集素ＰＮＡ在胃癌定位诊断和导向治疗中有着潜在的应用价值，对于人体某些表达Ｔ抗原的腺癌都可能具有作为导向治疗载体的研究前景。
Radioactive 131I and peanut agglutinin (PNA) were labeled with Iodogen method. 131I-PNA marker was injected intraperitoneally into nude mice bearing human stomach cancer. Tissue radioactivity distribution and gamma photography were measured at different times. On the 3rd day after administration, the tumor tissue showed a 4.30-fold increase in radioactivity, which was 3.76 times that of normal liver tissue and 3.89-fold that of muscle tissue. On the 7th day after administration, the tumor tissue was concentrated 131I. - PNA was 4.21 times that of normal stomach tissue, 6.05 times that of small intestine tissue, and 5.13 times that of large intestine tissue. Tumor imaging can be seen 48 hours and the 72-hour imaging is clear. The results of this experiment indicate that lectin PNA has potential application value in the diagnosis and targeted therapy of gastric cancer. For some human adenocarcinomas expressing T antigen, it may have the research prospects as a guide treatment vector.