【摘 要】
：
To study the efficacy and the mechanism of Colquhoumia root (Tripterygium hypoglaucum (Le,vL)Hutch) in the treatment of mesangial proliferation glomerulonephrit
【机 构】
：
Department of Nephrology
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To study the efficacy and the mechanism of Colquhoumia root (Tripterygium hypoglaucum (Le,vL)Hutch) in the treatment of mesangial proliferation glomerulonephritis (MsPGN), SD rats were injected with anti-thymocyte serum (ATS) to make MsPGN model (anti-Thy1 model). The rats were then divided into 3 groups: normal control group, anti-Thy1 model group and treatment group. Histopathological (HE, PAS), immunohistochemical, RT-PCR technique and computer imaging analysis system were used to evaluate mesangial matrix production, the expression of TGF-β1 protein and mRNA in the tissues of kidney.Our result showed that proteinuria and the ratio of extracellular matrix/glomerular capillaries area (ECM/CA) were increased significantly in model group. The expression of both TGF-β1 protein and mRNA in glomeruli was much higher in model group than in control group (P
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