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为了解低于正常生理情况下铝负载时胃肠道吸收铝的下限,将~(26)Al(100ng 70Bq)与微量自然铝(约1μg~(27)Al)共溶于枸橼酸钠溶液中,由一志愿者咽下,分别取6,12和18小时血标本,分离红血球而后用柱层析分馏血浆.铝的总量用石墨反应堆原子吸收光谱仪检查.同位素比率(~(26)Al/~(27)Al)用AMS(高能加速质谱仪)测量.该能量导致离子完全游离,~(26)Al可从同量异位素~(26)Mg潜在的干扰中分离,这是常规高解析质谱仪所无法完成的.测量出~(26)Al的极量是10~(-18)g,而同位素系数下限大约是10~(14).
In order to understand the lower limit of aluminum absorption in the gastrointestinal tract under the normal physiological conditions, ~ (26) Al (100ng 70Bq) and trace natural aluminum (about 1μg ~ (27) Al) were dissolved in sodium citrate solution Were swallowed by a volunteer, blood samples were taken for 6, 12 and 18 hours, respectively, and erythrocytes were separated and fractionated by column chromatography. The total amount of aluminum was examined by a graphite reactor atomic absorption spectrometer. / ~ (27) Al) was measured by AMS (High Energy Acceleration Mass Spectrometer), which resulted in the complete dissociation of the ions and the separation of ~ (26) Al from the potential interference of isobaric ~ (26) Mg High-resolution mass spectrometer can not do it.The measured amount of ~ (26) Al is 10 ~ (-18) g, while the lower limit of isotope is about 10 ~ (14).