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目的:通过谷丙转氨酶(ALT)、谷草转氨酶(AST)水平的变化,观察铁甲草抗大鼠酒精性和四氯化碳(CCl_4)慢性肝损伤的保护作用。方法:100只SD大鼠,雌雄各半,随机分为铁甲草高、低剂量组,联苯双酯组,模型组和正常对照组,除了正常对照组,各组大鼠分别灌服酒精(6.5g/kg)或皮下注射给予50%CCl_4花生油(5 mL/kg),连续8周,第5周开始给予相应药物干预,末次给药后,各组大鼠取血清,测定ALT和AST水平。结果:慢性酒精性肝损伤模型中正常对照组与模型组比较,AST、ALT差异有统计学意义(P<0.05),表明造模成功。与模型组比较,铁甲草高剂量组ALT和AST的水平降低(P<0.05)。CCl_4慢性肝损伤模型中正常对照组与模型组比较,AST、ALT差异有统计学意义(P<0.05),表明造模成功。与模型组比较,铁甲草高剂量组ALT和AST的水平降低(P<0.05),铁甲草低剂量组AST水平也降低(P<0.05)。结论:铁甲草有抗慢性酒精性肝损伤和CCl_4慢性肝损伤作用,高剂量组作用明显优于低剂量组,说明了保护作用与剂量呈正相关。
OBJECTIVE: To observe the protective effects of geranium against alcohol and carbon tetrachloride (CCl 4) -induced chronic liver injury in rats by the changes of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels. Methods: One hundred male Sprague Dawley rats were randomly divided into three groups: high and low dose armor, bifendate group, model group and normal control group. Except normal control group, 6.5g / kg) or subcutaneous injection of 50% CCl_4 peanut oil (5mL / kg) for 8 weeks, and the corresponding drug intervention was given at the 5th week. After the last administration, the rats in each group were taken serum to measure the levels of ALT and AST . Results: Compared with model group, the difference of AST and ALT in chronic alcoholic liver injury model was statistically significant (P <0.05), which showed that model making was successful. Compared with the model group, the levels of ALT and AST in the high dose of Armillaria melatona decreased (P <0.05). Compared with model group, the difference of AST and ALT in CCl 4 chronic liver injury model was statistically significant (P <0.05), which showed that the model was successful. Compared with the model group, the levels of ALT and AST in the high dose of Armillaria mellitus group decreased (P <0.05), and the AST level in the low dose armor group also decreased (P <0.05). CONCLUSION: The thyme has anti-chronic alcoholic liver injury and CCl4-induced chronic liver injury. The effect of high dose group is better than that of low dose group, indicating that the protective effect is positively correlated with dose.