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目的:探索丙氨酰-谷氨酰胺双肽在急性胰腺炎临床治疗中的应用效果。方法:选取我院于2014年8月至2015年8月间收治的60例急性胰腺炎患者作为临床研究对象,将其随机分为观察组与对照组,每组各30例患者,给予对照组患者临床常规治疗,确保患者获取足够的热量以及氮量等场外营养,在对照组治疗的基础上给予观察组患者丙氨酰-谷氨酰胺双肽治疗,对比分析两组患者的临床治疗效果。结果:经统计发现,治疗前,观察组与对照组患者在血清白蛋白、免疫球蛋白浓度等方面均不具有显著性差异(P>0.05),治疗后,两组患者的ALB、IgG、C反应蛋白浓度以及APACHEⅡ评分均有所增加,而观察组的增幅以及治疗后的水平值明显高于对照组(P<0.05),两组差异具有统计学意义。结论:丙氨酰-谷氨酰胺双肽配合全肠外营养治疗急性胰腺炎能够取得理想的临床应用效果,显著改善患者的营养状况,提高患者机体免疫能力,在临床实践中值得大力推广应用。
Objective: To explore the effect of alanyl-glutamine dipeptide in the clinical treatment of acute pancreatitis. Methods: Sixty patients with acute pancreatitis admitted from August 2014 to August 2015 in our hospital were selected as clinical study subjects. They were randomly divided into observation group and control group, 30 patients in each group were given control group Patients routine clinical treatment to ensure that patients get enough heat and nitrogen and other off-site nutrition in the control group based on the treatment group were given patients with alanyl-glutamine dipeptide treatment, comparative analysis of two groups of patients with clinical treatment . Results: According to the statistics, there was no significant difference in serum albumin and immunoglobulin concentration between the observation group and the control group before treatment (P> 0.05). After treatment, ALB, IgG, C Reaction protein concentration and APACHE Ⅱ score increased, but the increase in the observation group and the level after treatment were significantly higher than the control group (P <0.05), the difference between the two groups was statistically significant. Conclusion: Alanyl - glutamine dipeptide combined with total parenteral nutrition for acute pancreatitis can achieve the ideal clinical application effect, significantly improve the nutritional status of patients and improve the immune capacity of patients, which is worth popularization and application in clinical practice.