论文部分内容阅读
目的探讨冠心病患者行经皮冠状动脉介入术(percutaneous coronary intervention,PCI)后服用复方丹参滴丸在改善阿司匹林和/或氯吡格雷低反应性中的作用。方法冠心病患者409例,PCI术后规律服用阿司匹林、氯吡格雷,并给予复方丹参滴丸270 mg/次,3次/d,口服,连续2个月。分别于治疗2 d及2个月行血栓弹力图检查(thrombelastography,TEG),测量花生四烯酸(arachidonic acid,AA)诱导的血小板抑制率(AA%)、二磷酸腺苷(adenosine diphosphate,ADP)诱导的血小板抑制率(ADP%),观察不良反应发生情况。结果治疗2个月AA%[(84.77±5.69)%]、ADP%[(76.67±6.87)%]水平高于治疗2d[(77.34±5.41)%、(64.81±6.20)%](P<0.05);治疗2d筛查出AA%<50%者59例,ADP%<50%者133例;AA%<50%者治疗2个月AA%[(81.25±4.96)%]较治疗2d[(21.40±5.23)%]增高(P<0.05),52例AA%>50%;ADP%<50%者治疗2个月ADP%[(75.66±6.08)%]较治疗2d[(32.19±4.56)%]增高((P<0.05),109例ADP%>50%;治疗过程中均未发生脑出血、消化道出血。结论复方丹参滴丸可改善冠心病患者PCI术后血小板对阿司匹林/或氯吡格雷的低反应性。
Objective To investigate the effect of Fufang Danshen dripping pills on improving the low reactivity of aspirin and / or clopidogrel after percutaneous coronary intervention (PCI) in patients with coronary heart disease. Methods 409 patients with coronary heart disease, regular aspirin and clopidogrel after PCI, and given compound Danshen dripping pills 270 mg / time, 3 times / d, orally for 2 months. The thrombelastography (TEG) was performed on the 2nd and 2nd month of treatment. The platelet inhibition rate (AA%) induced by arachidonic acid (AA), the ratio of adenosine diphosphate (ADP) ) Induced platelet inhibition rate (ADP%), to observe the incidence of adverse reactions. Results The levels of AA% [(84.77 ± 5.69)%] and ADP% (76.67 ± 6.87)% at 2 months after treatment were higher than those of 2 days [(77.34 ± 5.41)% vs (64.81 ± 6.20)%] ); 2 days after treatment, 59 cases with AA% <50%, 133 cases with ADP% <50%; AA% 2 months after treatment for 2 months [(81.25 ± 4.96)%] 21.3 ± 5.23)%] (P <0.05), 52 cases of AA%> 50%; ADP% <50% of patients treated with ADP for 2 months [(75.66 ± 6.08)%] %] (P <0.05), and 109 cases of ADP%> 50%. No intracerebral hemorrhage and gastrointestinal bleeding occurred during the course of treatment.Conclusion Compound Danshen Dripping Pill can improve the efficacy of aspirin / Low Reactivity of Pigere.