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目的:探讨乳腺癌MMP2蛋白表达的临床意义。方法:应用免疫组织化学方法对乳腺癌石蜡标本进行检测,并与患者临床病理指标进行分析。结果:乳腺癌MMP2蛋白阳性反应率为45.8%,与肿瘤大小、腋淋巴结转移相关(P<0.05),MMP2阴性者生存期延长(P<0.05)。结论:MMP2参与了乳腺癌的发生、发展过程,可能是患者预后的不良指标。此结果为临床建立新的乳腺癌预后预测因子提供有价值的信息。
Objective: To investigate the clinical significance of MMP2 protein expression in breast cancer. Methods: Immunohistochemistry was used to detect paraffin-embedded specimens of breast cancer, and the clinical and pathological parameters were analyzed. Results: The positive rate of MMP2 protein in breast cancer was 45.8%, which was correlated with tumor size and axillary lymph node metastasis (P <0.05). The survival rate of MMP2 negative patients was longer (P <0.05). Conclusion: MMP2 is involved in the occurrence and development of breast cancer and may be a poor indicator of prognosis. This result provides valuable information for establishing a new prognostic factor for breast cancer.