冷凝集素型自身免疫性溶血性贫血少见,缺少治疗方法的研究。作者观察8例患者,其中女性6例,男性2例,年龄47-69岁。过去病史有咽峡炎、肺结核,传染性肝炎,结石性胆囊炎及对抗生素和止痛药过敏等。病程1年者3例,2年者1例,其余4例分别为5、8、11和30年。主诉畏寒,天冷时手脚脸青紫,出现血尿(2例)。血红蛋白81 126g/L。血清胆红素增高(7例)。患者Coombs试验阳性。冷凝集素效价512-128000。查出自身淋巴细胞毒6例。治疗:为降低冷凝集素滴度,作者用单采血浆法(PA)和单采淋巴细胞法(LA),对本组8例中4例进 Cold agglutinin-type autoimmune hemolytic anemia rare, the lack of treatment research. The authors observed 8 patients, including 6 females, 2 males, aged 47-69 years. Past history of angina, tuberculosis, infectious hepatitis, calculous cholecystitis and allergy to antibiotics and painkillers. Three patients had one-year disease course and one patient had two-year disease. The remaining four patients were 5, 8, 11 and 30 years respectively. Chief complaint of chills, cold hands and feet when the face bruising, hematuria (2 cases). Hemoglobin 81 126 g / L. Serum bilirubin increased (7 cases). Patient Coombs test positive. Cold agglutinin titer 512-128000. Detected his own lymphocyte poisoning in 6 cases. Treatment: In order to reduce cold agglutinin titers, the authors used apheresis (PA) and apheresis lymphoma (LA) in this group of 8 patients in 4 cases