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目的:探讨胶艾颗粒剂对子宫的收缩作用及性激素含量的影响。方法:应用肌张力换能器,测定胶艾颗粒剂不同剂量对小鼠离体子宫收缩作用;放射免疫方法测定去卵巢大鼠血清雌二醇、孕酮和睾丸酮含量;测定其产后2 h家兔在体子宫张力的影响及作用的时间和频率。结果:胶艾颗粒剂10、20、30g/kg三个剂量均对小鼠离体子宫收缩作用显著;胶艾颗粒剂15、30、45g/kg均能提高去卵巢大鼠血清雌二醇和孕酮含量;分别给予胶艾颗粒剂0.75、1.5、3.0g/kg 40 min后,使产后家兔子宫张力和收缩频率增加,60～90 min达到高峰效应。结论:胶艾颗粒剂能促进子宫平滑肌收缩,这有利于子宫出血时的止血和产后子宫复原。且作用时间持久、明显。其作用与剂量呈正比。
Objective: To investigate the effect of Jiaoyi granule on uterine contractility and sex hormones. Methods: Muscle tension transducer was used to determine the contractile effect of different doses of Jiaoyi granules on uterus in mice. The contents of estradiol, progesterone and testosterone in ovariectomized rats were determined by radioimmunoassay. Rabbit in vivo uterine tension and the role of time and frequency. Results: 10, 20 and 30 g / kg of Jiaoyi granule all had significant effect on uterine contractions in vitro in mice; 15, 45 and 45g / kg of Jiaoyi granule could increase serum estradiol and pregnancy Keto content. After giving GABA 0.75,1.5,3.0g / kg for 40 min respectively, the uterine tension and contractive frequency of postpartum rabbits increased, reaching the peak effect at 60-90 min. Conclusion: Jia AI granules can promote uterine smooth muscle contraction, which is conducive to hemostasis during uterine bleeding and postpartum uterine recovery. And the role of long-lasting, obvious. Its role is proportional to the dose.