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目的:探讨2型糖尿病合并高血压住院患者发生心房颤动的相关因素。方法:选取我院收治的2型糖尿病合并高血压发生心房颤动的患者112例为研究对象(房颤组,n=112例),同期选取与房颤组年龄及性别相匹配的未发生房颤的2型糖尿病合并高血压患者150例为对照组(n=150例),比较两组患者的一般临床资料、实验室检查指标等的差异,用Logistic回归方程分析患者并发房颤的相关因素。结果:与对照组比较,房颤组患者收缩压(SBP)较高,高血压比例高、服用ACEI/ARB类药物偏低(P<0.05)、左室射血分数(LVEF)偏低(P<0.05)、左房内径(LAD)长(P<0.05)、甘油三酯(TC)、低密度脂蛋白胆固醇(LDL-C)、糖化血红蛋白(HbA1c)、血肌酐(Scr)、B型脑钠肽(BNP)、高敏C反应蛋白(hs-CRP)、尿酸均较高(P<0.05);多因素Logistic回归方程分析提示:LAD、HbA1c、BNP、hs-CRP、尿酸是患者并发房颤的独立危险因素(P<0.05),而服用ACEI/ARB类药物为保护性因素。结论:LAD、HbA1c、BNP、hs-CRP、尿酸均可能是2型糖尿病合并高血压患者发生心房颤动的独立危险因素。
Objective: To investigate the related factors of atrial fibrillation in type 2 diabetic patients with hypertension. Methods: A total of 112 atrial fibrillation patients with type 2 diabetes mellitus and hypertension were enrolled in this study. Atrial fibrillation patients (n = 112) were enrolled in this study. Atrial fibrillation matched with age and gender of patients with atrial fibrillation 150 patients with type 2 diabetes mellitus complicated with hypertension were selected as the control group (n = 150). The general clinical data, laboratory indexes and other differences between the two groups were compared. Logistic regression equation was used to analyze the related factors of atrial fibrillation. Results: Compared with the control group, patients with atrial fibrillation had higher systolic blood pressure (SBP), higher proportion of hypertension, lower ACEI / ARB drugs (P <0.05) and lower left ventricular ejection fraction (LVEF) (P <0.05), LAD (P <0.05), triglyceride (TC), low density lipoprotein cholesterol (LDL-C), hemoglobin A1c, Scr, BNP, hs-CRP and uric acid were higher (P <0.05). Multivariate logistic regression analysis indicated that LAD, HbA1c, BNP, hs-CRP and uric acid were all associated with atrial fibrillation (P <0.05), while taking ACEI / ARB drugs as protective factors. Conclusion: LAD, HbA1c, BNP, hs-CRP and uric acid may be independent risk factors of atrial fibrillation in type 2 diabetic patients with hypertension.