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目的:探讨分析糖化血红蛋白、空腹血糖、血清C肽联合检查对妊娠期糖尿病筛查的临床效果观察及其临床意义。方法:选取2016年1月至2019年1月北大医疗鲁中医院收治的确诊妊娠期糖尿病孕妇40例作为观察组，妊娠期体检健康孕妇40例作为对照组。比较两组孕妇的糖化血红蛋白、空腹血糖、血清C肽水平，并对于联合筛查妊娠期糖尿病的效能进行评价。结果:观察组糖化血红蛋白明显高于对照组[（8.12 ± 1.14）%比（5.23 ± 0.15）%]，血清C肽明显低于对照组[（1.19 ± 0.28）nmol/L比（1.61 ± 0.22）nmol/L]，差异均有统计学意义（n P 0.05）；当糖化血红蛋白、空腹血糖和血清C肽指标联合检测时，灵敏度、特异度、阳性预测值、阴性预测值受试者工作特征（ROC）曲线下面积分别为98.65%、86.50%、88.42%、95.45%、0.943，均高于其他所有单项指标，差异有统计学意义（ n P < 0.05）。n 结论:糖化血红蛋白、空腹血糖和血清C肽指标联合检测能够更加准确地早期诊断妊娠期糖尿病。“,”Objective:To investigate the clinical effects of glycated hemoglobin, fasting blood glucose and serum C-peptide combined screening for gestational diabetes screening and its clinical significance.Methods:A total of 40 pregnant women with gestational diabetes mellitus (observation group) and 40 pregnant women (control group) in Peking University Medical Lu Zhong Hospital from January 2016 to September 2019 were enrolled. The changes of glycated hemoglobin, fasting blood glucose, and serum C-peptide were compared between the two groups, and the efficacy of combined screening for gestational diabetes was evaluated.Results:The glycated hemoglobin of the pregnant women in the observation group was significantly higher than that in the control group [(8.12 ± 1.14)% vs. (5.23 ± 0.15)%], the serum C-peptide of the pregnant women in the observation group was lower than that in the control group [(1.19 ± 0.28) nmol/L vs. (1.61 ± 0.22) nmol/L], and there were significant differences (n P0.05). When glycosylated hemoglobin, fasting blood glucose and serum C-peptide index was screened combinedly, the sensitivity, specificity, positive predictive value, negative predictive value and the areas under the receiver operation characteristic (ROC) curve were 98.65%, 86.50%, 88.42%, 95.45%, and 0.943, respectively. Compared with all other individual indicators, the difference was statistically significant (n P<0.05).n Conclusions:The combined detection of glycosylated hemoglobin, fasting blood glucose and serum C-peptide can more accurately diagnose gestational diabetes mellitus at an early stage.