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目的探讨吸入支气管扩张剂后深吸气量(inspiratory capacity,IC)变化率在诊断慢性阻塞性肺疾病(chronicobstructive pulmonary disease,COPD)中的临床意义。方法对COPD患者组130例,非COPD患者组79例,进行常规肺功能检查,检测到吸入支气管扩张剂后IC前后变化率及1秒率指标。结果以1秒率作为“金标准”计算吸入支气管扩张剂后IC变化率的敏感度、特异度、阳性似然比、阴性似然比、诊断比值比,Pearson Chi-Squares检验,Youden指数,绘制ROC曲线。其最佳截点8.44%,敏感度为86.9%,特异度为83.5%。结论吸入支气管扩张剂后IC变化率在COPD的诊断、鉴别诊断、初筛具有临床意义。
Objective To investigate the clinical significance of inspiratory capacity (IC) change rate in the diagnosis of chronic obstructive pulmonary disease (COPD) after bronchodilator inhalation. Methods 130 cases of COPD patients, 79 cases of non-COPD patients, routine pulmonary function tests to detect bronchodilator inhalation after IC before and after the change rate and 1 second rate indicators. Results The sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, Pearson Chi-Squares test, Youden index , Draw ROC curve. The best cut point of 8.44%, sensitivity was 86.9%, specificity was 83.5%. Conclusion The change rate of IC after bronchodilator inhalation has clinical significance in the diagnosis, differential diagnosis and primary screening of COPD.