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目的探讨心肌肌钙蛋白I(cTn I)与肌酸激酶同工酶(CK-MB)在小儿病毒性心肌炎(VMC)诊断中的意义。方法 cTn I采用化学发光法,CK-MB采用速率法测定,对临床确诊的68例VMC患儿,在不同时间段进行上述两项检测,并与60例健康儿童的检测结果进行比较。结果 68例患儿的cTn I在VMC起病后4～6 h开始升高,12～24 h达到高峰;CK-MB在VMC起病后8～12 h开始升高,24～48 h达到高峰。两项指标峰值与对照组比较差异有统计学意义(P<0.05)。结论检测cTn I对诊断小儿病毒性心肌炎有较高的敏感性和特异性,可作为小儿病毒性心肌炎早期诊断的可靠指标。
Objective To investigate the significance of cTnI and CK-MB in the diagnosis of viral myocarditis (VMC) in children. Methods The chemiluminescence method and CK-MB method were used to determine cTn I in 68 patients with VMC clinically. The two tests were performed at different time points and compared with the results of 60 healthy children. Results 68 cases of cTn I began to rise at 4 ~ 6 h after onset of VMC and peaked at 12 ~ 24 h. CK-MB began to rise at 8 ~ 12 h after onset of VMC and peaked at 24 ~ 48 h . The peak value of the two indicators compared with the control group was statistically significant (P <0.05). Conclusions The detection of cTn I has high sensitivity and specificity for the diagnosis of viral myocarditis in children and can be used as a reliable indicator of early diagnosis of viral myocarditis in children.