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高血压是肾移植术后常见的并发症。肾移植术后用环孢素的病人28%～75%有持续性高血压。其病因尚未确定,但已知环孢素、低镁和皮质类固醇等因素可引起血压升高。由环孢素引起的高血压在治疗上首选钙通道阻滞剂二氢吡啶类、硫氮唑酮和异搏定等药物。当中断使用钙通道阻滞剂时要特别注意环孢素的血浓度和对肾功能的监控。高血压伴有水肿时,建议采用速尿和丁苯氧酸。血管紧张素转换酶阻滞剂对环孢素引起的高血压无明显作用,但治疗顽固性高血压是十分有效的,一旦使用要对肾功能进行严密监测一至二周,以防出现肾小球滤过率的降低。
Hypertension is a common complication after kidney transplantation. Patients with cyclosporine after renal transplantation 28% to 75% of persistent hypertension. The etiology has not been determined, but factors such as cyclosporine, low magnesium and corticosteroids are known to cause elevated blood pressure. High blood pressure caused by cyclosporine in the treatment of choice for the calcium channel blockers dihydropyridines, and other drugs thiadiazole and verapamil. When discontinuing calcium channel blockers, pay special attention to the blood levels of cyclosporine and the monitoring of renal function. High blood pressure associated with edema, it is recommended to use furosemide and butoxybenzene. Angiotensin-converting enzyme blockers have no effect on cyclosporine-induced hypertension, but treatment of refractory hypertension is very effective, once used to monitor renal function for one to two weeks, to prevent the occurrence of glomerular Reduced filtration rate.