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目的研究不同年龄、性别人群血液中硬骨素水平与骨密度之间的相关性。方法随机选取20~90岁男性和女性志愿者各100名,用酶联免疫法测定其血液中硬骨素水平,采用双能量X线骨密度测定仪测定其全身骨密度值(BMD)。结果男性血液中平均硬骨素水平比女性明显高(P<0.001);随着年龄的增长,人群血液中硬骨素水平相应增高;在相同骨密度水平,老年人血液中硬骨素水平较年轻人高。结论男性血液中硬骨素水平较女性高,血液中硬骨素水平随年龄增长而增高。
Objective To study the correlation between the level of sclerostin and bone mineral density in different ages and sexes. Methods A total of 100 male and female volunteers aged 20-90 years were randomly selected. The level of sclerostin in the blood was determined by enzyme-linked immunosorbent assay (ELISA). Total body mineral density (BMD) was measured by dual energy X-ray absorptiometry. Results The average level of sclerostin in men was significantly higher than that in women (P <0.001). The level of sclerostin in the blood increased with age. At the same level of bone mineral density, the level of sclerostin in the blood of the elderly was higher than that of the young . Conclusion Male patients with higher levels of sclerostin in blood, sclerosing blood levels increased with age.