引言生理学虽然早在1911年就已怀疑多巴胺具有生化作用,但直到1957年Blaschko才提出,它除了作为去甲肾上腺素生物合成的前体,还有不相关的独立的外周生理作用。Carlsson等报道,多巴胺具有中枢作用,并提出生化-药理证据证实多巴胺本身参与了脑的生化过程。 INTRODUCTION PHYSIOLOGY Although it was suspected as early as 1911 that dopamine had a biochemical effect, it was not until 1957 that Blaschko suggested that in addition to acting as a precursor to norepinephrine biosynthesis, there is an independent, peripheral physiology independent of that of dopamine. Carlsson et al reported that dopamine has a central role and proposed biochemical-pharmacological evidence that dopamine itself is involved in brain biochemical processes.