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探讨高龄产妇合并甲状腺功能减退(甲减)对妊娠结局的影响。回顾性分析2013年9月至2016年8月,北京美中宜和妇儿医院收治的高龄合并甲状腺功能减退产妇32例(甲减组),亚临床甲状腺功能减退产妇40例(亚甲减组),选择同期甲状腺功能正常的高龄产妇75例(对照组),比较三组研究对象围生期结局的差异。采用SPSS 17.0统计软件,多组间计量资料比较采用方差分析,计数资料比较采用χ~2检验,P<0.05为差异有统计学意义。结果显示,甲减组剖宫产率53.12%(17/32),亚甲减组剖宫产率55.00%(22/40),高于对照组29.33%(22/75),差异均有统计学意义(χ~2=4.502、6.229,P<0.05)。甲减组顺产率31.25%(10/32),低于对照组56.00%(42/75),差异有统计学意义(χ~2=6.985,P<0.05)。孕期甲减组妊高症、妊娠期糖尿病、胎盘早剥、贫血的发生率高于亚甲减组和对照组,差异有统计学意义(χ~2=6.475、6.705、7.495、7.442,P=0.039、0.035、0.024、0.020)。围产期三组孕妇早产、羊水粪染、胎膜早破、产后出血发生率差异均有统计学意义(χ~2=6.174、10.357、7.982、6.174,P=0.046、0.006、0.018、0.046)。三组新生儿低体质量和胎儿窘迫的发生率差异有统计学意义(χ~2=8.152、6.174,P=0.017、0.046)。
To explore the effect of hypothyroidism (hypothyroidism) on pregnancy outcome in elder mothers. From September 2013 to August 2016, 32 patients with hypothyroidism (hypothyroidism), 40 with hypothyroidism (subclinical hypothyroidism) were retrospectively analyzed from September 2013 to August 2016 in Beijing. ), Select the same period thyroid function of normal elderly maternal 75 cases (control group), the three groups were compared the perinatal outcome differences. Using SPSS 17.0 statistical software, the measurement data between groups were compared using analysis of variance, count data were compared using χ ~ 2 test, P <0.05 for the difference was statistically significant. The results showed that the rate of cesarean section was 53.12% (17/32) in hypothyroidism group and 55.00% (22/40) in sub-hypothyroidism group, which was higher than that in control group (29.33%, 22/75) Significance (χ ~ 2 = 4.502, 6.229, P <0.05). The incidence of hypothyroidism was 31.25% (10/32), which was lower than that of the control group (56.00%, 42/75). The difference was statistically significant (χ ~ 2 = 6.985, P <0.05). Pregnancy hypothyroidism pregnancy-induced hypertension, gestational diabetes mellitus, placental abruption, the incidence of anemia was higher than the methylene hypothyroidism group and the control group, the difference was statistically significant (χ ~ 2 = 6.475,6.705,7.495,7.442, P = 0.039, 0.035, 0.024, 0.020). There were significant differences in the incidence of preterm birth, meconium-stained amniotic fluid, premature rupture of membranes and postpartum hemorrhage between the three groups during perinatal period (χ ~ 2 = 6.174,10.357,7.982,6.174, P = 0.046,0.006,0.018,0.046) . The incidence of low birth weight and fetal distress among the three groups was statistically different (χ ~ 2 = 8.152, 6.174, P = 0.017,0.046).