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长期应用高浓度氧能引起肺损伤,其严重度与氧浓度、接触时间及个体的敏感性有关。本文对8只成年雄性健康的狒狒(体重13～18kg),在全麻下安接动脉插管和心导管并给持续机械通气,分别检测吸入40%和100%氧状态下的肺功能、血液动力学、血气和支气管肺泡灌洗液(BALF)中的细胞和生化成分。然后用F_IO_2 1.0持续机械通气5～7天,在此期间连续观察上述指标,以便早期发现肺损伤的迹象,直至出现
Long-term use of high concentration of oxygen can cause lung injury, the severity of oxygen concentration, exposure time and individual sensitivity. Eight adult male baboons, weighing 13-18 kg, were anesthetized with arterial cannulation and cardiac catheterization and were given continuous mechanical ventilation. Lung function was measured at 40% and 100% oxygen levels respectively, and blood Kinetics, blood gas and cells and biochemical composition in bronchoalveolar lavage fluid (BALF). Followed by continuous mechanical ventilation with F_IO_2 1.0 for 5 to 7 days, during which time the above indices were continuously observed in order to detect early signs of lung injury until the appearance of