所谓自身免疫性疾病是指自身免疫反应引起组织损伤的疾病。在临床方面,有的自身免疫病己明确是自身抗体直接作用于自身抗原产生的自身免疫应答所致;有的则难以证实自身免疫应答是组织损伤的原因。但是在自身免疫病患者中都能查出自身抗体,这一点却是一致的。至今己无人对自身免疫现象及自身免疫性疾病的存在发生怀疑。最近在日本把大部分自身免疫病列为难治疾病, Autoimmune diseases are autoimmune diseases that cause tissue damage. In the clinical aspect, some autoimmune diseases have been clearly caused by the autoimmune response caused by the autoantibodies acting directly on the autoantigen. However, it is difficult to confirm that the autoimmune response is the cause of the tissue damage. However, autoantibodies can be detected in patients with autoimmune diseases, which is consistent. No one has so far questioned the existence of autoimmunity and autoimmune diseases. Most autoimmune diseases in Japan have recently been classified as refractory to the disease,