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本文研究了国产硫辛酸对酒石酸锑钾的解毒作用.结果证明硫辛酸对酒石酸锑钾的急性及亚急性毒性均有非常显著的解毒作用.小白鼠腹腔注射酒石酸锑钾后,立即以130毫克/公斤的硫辛酸灌胃或皮下注射,可分别使酒石酸锑钾的急性LD_(50)提高1.6和1.9倍.在急性试验中,酒石酸锑钾为LD_(95)时,2-3分子硫辛酸可对抗1分子酒石酸锑钾;在亚急性试验中,酒石酸锑钾为LD_(50)时,1分子硫辛酸即可对抗1分子酒石酸锑钾.腹腔注射酒石酸锑钾LD_(50)后3小时皮下注射硫辛酸,可完全保护小白鼠免于死亡.硫辛酸性质稳定,口服吸收良好,在锑剂中毒出现症状后仍然有效,值得在临床试用.
In this paper, domestic lipoic acid detoxification of antimony potassium tartrate was studied.The results showed that lipoic acid had a very significant detoxification effect on acute and subacute toxicity of antimony potassium tartrate.After intraperitoneal injection of antimony potassium tartrate into mice, 130 mg / Kg of lipoic acid intragastrically or subcutaneously increased the acute LD 50 of antimony potassium tartrate by 1.6 and 1.9 times, respectively. In an acute test, when antimony potassium tartrate was LD 95, 2-3 molecules of lipoic acid were In the subacute test, one molecule of lipoic acid can antagonize one molecule of antimony potassium tartrate when sub-acute antimony potassium tartrate LD_ (50) .After three hours’ intradermal injection of antimony potassium tartrate LD_ (50) Lipoic acid, can completely protect the mice from death.Lipoic acid is stable, good oral absorption, still effective after the symptoms of antimony poisoning, it is worth in clinical trials.