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淋巴管新生在胚胎发育、外伤修复、炎症转归、肿瘤转移和器官移植后排斥反应等方面起着重要作用。除淋巴管内皮细胞外,淋巴管内皮祖细胞参与淋巴管新生。淋巴管内皮祖细胞表达CD34、CD133和VEGFR-3,在趋化因子作用下由骨髓动员入外周血,继而迁入局部组织。经VEGF-C等生长因子诱导向淋巴管内皮细胞分化,参与淋巴管新生。VEGF-C/VEGFR-3信号途径在LEPCs分化和淋巴管新生方面起着关键调控作用,故VEGF-C和VEGFR-3可作为基因治疗的靶点,调节淋巴管内皮细胞向内皮细胞分化,从而促进或抑制淋巴管新生。阐明内皮祖细胞在淋巴新生方面的作用机制对于探讨肿瘤淋巴转移和器官移植后存活等具有重要意义。
Lymphangiogenesis plays an important role in embryonic development, trauma repair, inflammatory outcome, tumor metastasis and rejection after organ transplantation. In addition to lymphatic endothelial cells, lymphatic endothelial progenitor cells participate in lymphangiogenesis. The lymphatic endothelial progenitor cells express CD34, CD133 and VEGFR-3, mobilize bone marrow into the peripheral blood by chemokines, and then migrate into the local tissues. After VEGF-C and other growth factors induced lymphatic endothelial cell differentiation, involved in lymphangiogenesis. The VEGF-C / VEGFR-3 signaling pathway plays a key regulatory role in LEPCs differentiation and lymphangiogenesis, so VEGF-C and VEGFR-3 are targets of gene therapy that regulate the differentiation of lymphatic endothelial cells to endothelial cells and thus Promote or inhibit lymphangiogenesis. To clarify the mechanism of endothelial progenitor cells in lymphoid neoplasm is important for the study of lymphatic metastasis and survival after organ transplantation.