论文部分内容阅读
本文报道9个估计具有血管紧张素转化酶抑制活性的N-(4-乙氧羰基-4-取代丁酰基)-N-取代甘氨酸及其相应叔丁酯的合成和鉴定。药理初试结果,化合物Ⅶ_7和Ⅶ_9显示明显降压活性。
The synthesis and characterization of nine N- (4-ethoxycarbonyl-4-substituted butyryl) -N-substituted glycines and their corresponding t-butyl esters estimated to have angiotensin-converting enzyme inhibitory activity are reported herein. Pharmacological first test results, compounds VII_7 and VII_9 showed significant antihypertensive activity.