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血药浓度的三种时间因素可影响抗生素的给药方案:(1)稳态峰浓度与最低抑菌浓度比值(Css_(max)/MIC),它关系到血液中细菌的清除和抗菌药物进入感染组织;(2)大于MIC的血药浓度维持时间(超过MIC的时间/给药间隔)与维持有效的组织浓度有关;(3)强度指数(II),即给药间隔中大于MIC值的AUC(药时曲线下面积)部分.综合影响疗效的血药浓度的幅度和维持时间两方面的因素,II在制定给药方案和比较治疗同种及不同细菌感染的
Three time factors of blood concentration can influence the administration of antibiotics: (1) The ratio of steady state peak concentration to minimum inhibitory concentration (Css max / MIC), which is related to the clearance of bacteria in the blood and the entry of antibiotics Infected tissue; (2) blood plasma concentration maintenance time greater than MIC (time over MIC / dosing interval) is associated with maintenance of effective tissue concentration; (3) intensity index (II) AUC (area under the curve of drug time) .Consider the two factors that affect the efficacy of the concentration of plasma concentration and maintenance time, II in the formulation of drug delivery programs and compare the treatment of the same and different bacterial infections