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目的检测系统性红斑狼疮(SLE)患者血清中抗载脂蛋白A-1(Apo A-1)抗体变化,并探讨其临床意义。方法选取2011年8月~2013年5月于河北北方学院附属第二医院进行诊治的47例SLE患者及40例健康体检者作为研究对象,详细记录患者临床资料并检测血清中抗Apo A-1抗体、dsDNA抗体及其他生化指标,根据不同临床指标进行分组并进行统计学分析。结果健康对照组相比,SLE患者抗Apo A-1抗体水平升高(35.8±5.2)U/mL vs(14.7±3.1)U/ml,P<0.05,其中活动期患者抗Apo A-1抗体升高更为显著(40.1±6.7)U/ml;抗dsDNA抗体阳性SLE患者血清中抗Apo A-1抗体水平较对照组均显著升高(39.0±5.8)U/ml vs(30.8±6.1)U/ml,P<0.05)。相关性分析结果显示抗Apo A-1抗体与SLEDAI呈正相关(r=0.627,P<0.05),与HDL水平呈负相关(r=-0.453,P<0.05)。结论 SLE患者外周血中异常表达的抗Apo A-1抗体可能与SLE疾病活动有关,可作为反映病情活动的有效指标。
Objective To detect the change of serum apolipoprotein A-1 antibody in patients with systemic lupus erythematosus (SLE) and to explore its clinical significance. Methods Forty-seven patients with SLE and 40 healthy subjects who were diagnosed and treated in the Second Affiliated Hospital of Hebei North University from August 2011 to May 2013 were selected as the research object. The clinical data of the patients and the detection of anti-Apo A-1 Antibody, dsDNA antibody and other biochemical indicators, according to different clinical indicators were grouped and statistical analysis. Results The level of anti-Apo A-1 antibody in SLE patients was significantly higher than that in healthy controls (35.8 ± 5.2) U / mL vs (14.7 ± 3.1) U / ml, P <0.05 The level of anti-Apo A-1 antibody in serum of patients with anti-dsDNA antibody-positive SLE was significantly higher than that of the control group (39.0 ± 5.8) U / ml vs (30.8 ± 6.1) U / ml, P <0.05). Correlation analysis showed that anti-Apo A-1 antibody was positively correlated with SLEDAI (r = 0.627, P <0.05) and negatively correlated with HDL (r = -0.453, P <0.05). Conclusion The abnormal expression of anti-Apo A-1 antibody in the peripheral blood of patients with SLE may be related to SLE disease activity, which can be used as an effective indicator of disease activity.